Personally, I'm fine with Mosquito lagoon. I just wish I could get out more often.
Sight-fishing reds in scary-skinny water still thrills me like no other type of fishing.
IMHO redfish can be just as spooky and difficult as Islamorada bones, or as easy as crappie in a pond.
Like DOC, as long as I can get away every once in a while I'm good.

That said, if I were young and possessed, the keys would certainly be on my shortlist.